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  • Writer's pictureChemistry.

Better Know a Terpene: Caryophyllene

Updated: Nov 21, 2019

Terpene: Caryophyllene

Type: Sesquiterpene

Found In: Black Pepper, Clove, Cinnamon

Flavor: Spice, Pepper, Clove

Effect: Pain Relief, Calming, Relaxed

Caryophyllene is one of the most common terpenes found in cannabis. Ever get a tickle in your nose and sneeze after hitting one of our vapes? Chances are it’s high in Caryophyllene. This sesquiterpene has a spicy aroma, similar to cracked black pepper. It’s also present in many herbs and spices, including clove, cinnamon and basil.

And Caryophyllene may just be unrivaled in terms of its healing properties. It’s the only known terpene to bind directly to the endocannabinoid system’s CB2 receptor. The body’s CB2 receptors are primarily responsible for the therapeutic benefits we receive from phytocannabinoids, not the heady psychoactive effects associated with CB1 receptors.

Caryophyllene binds exclusively with CB2 receptors, helping with inflammation, pain, atherosclerosis and osteoporosis. Studies have shown Caryophyllene to be directly beneficial for colitis, osteoarthritis, diabetes, cerebral ischemia, anxiety and depression, liver fibrosis and Alzheimer-like diseases. In cancer studies, Caryophyllene alone was found to stimulate apoptosis (the death of cancer cells) and suppress tumor growth.

A mighty terpene, indeed.

Caryophyllene is also excellent for stress and anxiety. And we've got the science to back it up. Scientists found that roundworms lived 22% longer thanks to reduced stress levels from exposure to the spicy terpene. And mice exposed to Caryophyllene become less stressed and more open to exploring complex mazes without the motor impairment experienced by their counterparts on diazepam.

So if you’re dealing with stress, anxiety, inflammation, or autoimmune issues, look for strains high in Caryophyllene. The full extent of Caryophyllene’s healing potential is still unknown, but the research we do have is incredibly promising for this sneeze-inducing terpene.

Chemistry Products Containing Caryophyllene:



BLUE KUSH @ 2.36%

99 COOKIES @ 2.32%


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